Antimetastatic Activity of Acteoside, a Phenylethanoid Glycoside.

Lianqiaoxinoside B, a novel caffeoyl phenylethanoid glycoside from Forsythia suspensa.

Chemical investigation of the 70% ethanol extract of the unripe fruits of Forsythia suspensa resulted in the isolation of a novel caffeoyl phenylethanoid glycoside, lianqiaoxinoside B, together with the known compound forsythoside H. The new compound was elucidated to be 1'',2''-[β-(3,4,-dihydroxylphenyl)-α,β-dioxoethanol]-3''-O-caffeoyl-O-α-rhamnopyranosyl-(1→6)-O-β-glucopyranoside by extensiv...

Physocalycoside, a new phenylethanoid glycoside from Phlomis physocalyx Hub.-Mor.

A new phenylethanoid tetraglycoside, physocalycoside (2), was isolated from the aerial parts of Phlomis physocalyx. Its structure was identified as 3-hydroxy-4-methoxy-beta-phenylethoxy-O-[alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-rhamnopyranosyl-(1-->3)]-4-O-feruloyl-[beta-D-glucopyranosyl-(1-->6)]-beta-D-glucopyranoside, on the basis of spectroscopic evidence. In addition, one known iridoid glu...

A Phenylethanoid Glycoside and Other Constituents from the Fruits of Forsythia koreana

The Oleaceae is a family of medium size with 25 genera and about 600 species. With regard to chemical constituents, it has been quite extensively investigated. It is mainly characterized by the presence of iridoid glucosides and phenylethanoid derivatives in the form of esters and glycosides of tyrosol (p-hydroxyphenyl-ethanol) and in particular the closely related dopaol (3,4-dihydroxyphenyl-e...

Antitumor and Antimetastatic Activity of

Antimetastatic activity of a preventive cancer vaccine.

The development of prophylactic cancer vaccines that protect healthy hosts from tumor development leaves open the question whether such vaccines are also effective against established tumors and metastases. We tested the therapeutic activity of a proven prophylactic anti-HER-2/neu vaccine against successive stages of mammary carcinoma progression in HER-2/neu transgenic mice. The vaccine consis...